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Van Wyk Grumbach Syndrome
Author(s):
1. Maira Riaz: Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan
2. Mohsina Noor Ibrahim: Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan
3. Taj Muhammad Laghari: Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan
4. Misbah Iqbal Hanif: Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan
5. Jamal Raza: Department of Paediatrics, National Institute of Child Health,Karachi,Pakistanof Paediatrics, National Institute of Child Health,Karachi,Pakistan
Abstract:
Van Wyk Grumbach syndrome is well known for protracted hypothyroidism, characterised by multicystic ovaries (normal size ovaries contain many follicles of various sizes), isosexual precocious puberty and delayed skeletal growth. A series of ten children with Van Wyk Grumbach syndrome is been presented with their clinical features, biochemical and radiological pro le and management. Patients showed a noteworthy improvement upon thyroxine therapy. It is vital to keep this entity in consideration and; hence, should investigate for thyroid status during the evaluation of ovarian cysts. Thyroxin replacement after establishing the diagnosis early can prevent the patient from going through extensive workup and surgeries.
Page(s): 1332-1334
DOI: DOI not available
Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 30, Issue: 12, Year: 2020
Keywords:
Multicystic ovaries , Isosexual precocious puberty , Hypothyrodism
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