Abstract:
The present study was designed to determine the hepatoprotective effects of fenugreek seeds extract supplementation on thioacetamide induced liver damage in rats. For this purpose 24 male Sprague Dawley rats were distributed into 4 groups (n=60. Group I remained untreated throughout the study. Group II and Group III received thioacetamide intraperitoneally 200mg/kg body weight on alternative days for 8 weeks. Group III and Group IV received 2ml of 2% Fenugreek seeds extract orally daily from 4th week till 8th week of the study. Next day after completion of study, the rats were weighted and decapitated; blood was collected for plasma for glucose and lipid profile analysis. Marked reduced plasma glucose level and HDL level and increased triglyceride, cholesterol, LDL, VLDL and total lipid level were observed in test group. The Fenugreek seeds extract supplementation significantly increased plasma glucose and HDL level and remarkably decreased triglyceride, cholesterol, LDL, VLDL and total lipid level in Test+Supplement group whereas glucose and lipid profile were reduced in supplement group showing supplement is hypoglycemic and hypolipidemic. The results of this study confirmed that treatment with Fenugreek seeds extract successively ameliorates the altered glucose and lipid profile in liver damage induced by thioacetamide in male rats.
Page(s):
2003-2008
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 33, Issue: 5, Year: 2020
Keywords:
triglyceride
,
cholesterol
,
hepatoprotective effects
,
fenugreek seeds