Transient pseudohypoaldosteronism type 1 associated with urinary tract infection and posterior urethral valve: case report | [Pakistan Journal of Pathology • 2019]

Author(s):

1. Alveena Younas: Armed Forces institute of Pathology (National University of Medical Sciences), Rawalpindi, Pakistan

2. Asif Ali: Armed Forces institute of Pathology (National University of Medical Sciences), Rawalpindi, Pakistan

3. Saima Shakil Malik: Armed Forces institute of Pathology (National University of Medical Sciences), Rawalpindi, Pakistan

4. Muhammad Aamir: Armed Forces institute of Pathology (National University of Medical Sciences), Rawalpindi, Pakistan

5. Zujaja Hina Haroon: Armed Forces institute of Pathology (National University of Medical Sciences), Rawalpindi, Pakistan

6. Muhammad Tahir Khadim: Armed Forces institute of Pathology (National University of Medical Sciences), Rawalpindi, Pakistan

Abstract:

Persistent, severe neonatal hyponatremia coexisting with hyperkalemia and metabolic acidosis though not a very common yet is a fatal condition. Among the differential diagnosis of gastrointestinal fluid loss, salt loosing congenital adrenal hyperplasia and type IV renal tubular acidosis, Pseudohypoaldosteronism Type 1 (PHA 1) should also be kept in mind. Here we report a case of 2 months old baby boy with poor feeding, failure to thrive and persistent vomiting. His biochemical profile revealed severe hyponatremia, hyperkalemia, metabolic acidosis and raised Plasma Aldosterone and Plasma Active Renin Mass Concentration (ARC). Child had severe multi drug resistant urinary tract infection by Klebsiella oxytoca complicating obstructive uropathy caused by posterior urethral valve. Subsequently the PHA 1 subsided once the child was treated successfully for urinary tract infection and posterior urethral valve was removed surgically. Thus, highlighting association of urinary tract infection and posterior urethral valve with development of transient PHA type-1.

Page(s): 113-115

DOI: DOI not available

Published: Journal: Pakistan Journal of Pathology, Volume: 30, Issue: 4, Year: 2019

Keywords:

Urinary tract infection , Transient pseudohypoaldosteronism type 1 , Neonatal hyponatremia

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