Author(s):
1. Sana Akhlaq:
Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan
2. Saba Khaliq:
Department of Physiology, University of Health Sciences, Lahore, Pakistan.
Abstract:
The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional comparative study comprised 80 subjects with confirmed normal glucose tolerance values. Parameters assessed included secreted frizzled related protein-4, fasting glucose, random glucose, fasting insulin, homeostasis model of assessment of insulin resistance and waist-toheight ratio values. Those without a diabetic background had significantly higher frizzled related protein-4 levels (p=0.02). Although subjects with family history of diabetes showed higher mean fasting glucose, waist circumference and waist-to-height ratio, these differences were not statistically significant ( p>0.05). However, there was a strong positive correlation with waist circumference, waistto-height ratio, fasting insulin and homeostasis model of assessment of insulin resistance (p=0.0001). There was no signicfiant correlation of diabetic background with frizzled related protein-4 SFRP-4, homeostasis model of assessment of insulin resistance and waist-to-height ratio (p>0.05).
Page(s):
1338-1341
Published:
Journal: Journal of Pakistan Medical Association, Volume: 74, Issue: 7, Year: 2024
Keywords:
Type 2
,
Diabetes mellitus
,
Metabolic syndrome
,
Insulin resistance
,
Diabetes mellitus
,
family
,
Insulin
,
Blood Glucose
,
Waist Circumference
,
NAFLD
,
Mass screening
,
CrossSectional Studies
,
Waistheight ratio
,
Frizzled related protein 4
,
Wnt signalling pathway
References:
References are not available for this document.
Citations
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