Zinc deficiency as severity predictor in pediatric dengue viral infection : a meta-analysis | Pakistan Journal of Medical and Health Sciences 2020

Author(s)

Firyal Nadiah Rahmah Faculty of Medicine,Universitas Brawijaya. Veteran Street 5 Malang,Indonesia

Salsabila Nabilah Rifdah Faculty of Medicine, Airlangga University.,Airlangga Street 4 Surabaya,Indonesia

Ricky Indra Alfaray Faculty of Medicine, Airlangga University.,Airlangga Street 4 Surabaya,Indonesia

Andry Gonius Faculty of Medicine,Universitas Brawijaya. Veteran Street 5 Malang,Indonesia

Sugeng Soegijanto Medical Faculty, Airlangga University, Tropic Medicine Department,Surabaya,Indonesia

Abstract

Background: Endothelial cells in dengue viral infection (DVI) produce Tumor Necrosis Factor (TNF-a) in abundant number from zinc deficient patients rather than non deficient. This finding suggest zinc is protective for maintenance of endothelial cell, thus decrease the severity of dengue viral infection. Aim: In this meta-analysis, we will compare the zinc serum in deficient and non deficientpatients from several studies as predictor in dengue viral infection. Methods: We included all research articles in pediatric patients diagnosed with Dengue Fever or Dengue Hemorrhagic Fever with information on zinc serum available. Zinc deficiency is reported to be below 9,18 µmol/LThe severity is divided into dengue fever against dengue hemorrhagic fever. Result: There were 217 patients included in this study. The meta-analysis showed that there are significant difference in both results (OR 6.32 [3.50 - 11.40], p = 0.0003; I2: 84%, p < 0.00001). Conclusion: Zinc deficiency in pediatric dengue viral infection can be used for the predictor of severityin dengue viral infection. Zinc supplementation can be mandatory for dengue viral infection treatment

Publication Details

Page(s) 1568-1570

DOI DOI not available

Published Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 4, Year: 2020

Keywords

Dengue fever zinc deficiency dengue hemorrhagic fever Dengue viral infection

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