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X-Ray diffraction studies on inhibitor of platelet aggregation dictamnine.
Author(s)
N. Sultana Pharmaceutical Research Centre, PCSIR Laboratories Complex, Karachi, Pakistan
M. I. Choudhary International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan
F. Akhter International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan
Abstract
In the course of our studies on the chemical constituents of the aerial parts of Skimmia laureola, a number of coumarins isogospherol (1) heraclenol (2), (+)-7-methoxy-6-(2`R-methoxy-3`-hydroxy-3`-methyl butyl) coumarin (3), 5, 8-dimethoxy coumarin-2H-1­benzopyran-2-one (4), 7-methoxy-6-[2`-oxo-3`-methyl butyl] coumarin (5), (+)-ulopterol (6), were isolated. In addition various quinoline alkaloids, 4-methoxy-l-methyl-3-(2`S -acetoxy -3`-ene butyl) -2-quinolone (7), 4-methoxy-l-methyl-3-(2`S-acetoxy-3`-hydroxy butyl)-2-quinolone (8), 3-hydroxy-2, 2, 6-trimethyl -3, 4, 5, 6- tetrahydro-2H-pyrano [3, 2- c] quinoline-5-one (9), 4-methoxy-l-methyl-3-(2`-oxo-3`-methyl butyl)-2-quinolone (10), 4-methoxy-l-methyl-3-(2`S-hydroxy-3`-ene butyl) -2-quinolone (11), methyl isoplatydesmine (12) ribalinin (13) and dictamnine (14) were also isolated from Skimmia laureola. The structures were established by spectroscopic studies. In this paper we report the X-ray diffraction studies on inhibitor of platelet aggregation dictamnine (14).
Publication Details
Page(s) 194-197
DOI DOI not available
Published Journal: Journal of Chemical Society of Pakistan, Volume: 29, Issue: 2, Year: 2007
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