Soil salinity is a critical threat to global agriculture, with rising climate variability accelerating salinization and reducing cultivable land, thus endangering food security. This study investigates the efficacy of exogenous mannitol (MN) application in mitigating the negative consequences of NaClinduced salinity in wheat (Triticum aestivum L.). Three concentrations of mannitol (0, 50, and 100 ppm) were evaluated under three salinity levels (0, 50, and 100 mM NaCl) using a completely randomized design (CRD) at HSTU, Bangladesh. Results showed that 100 ppm mannitol (MN2) significantly enhanced growth parameters including plant height, leaf number, root length, leaf area, and biomass accumulation (fresh and dry weight of leaves, culm, and roots) under salt stress. Physiological improvements were observed through elevated levels of chlorophyll a, chlorophyll b, total chlorophyll, carotenoids, and improved water status (RWC, WSD, WRC, and WUC). Yield attributes such as 1000-grain weight (36.65 g), grain yield (2.86 g plant?¹), stover yield, biological yield, and harvest index (40.36%) were notably improved. Mannitol also mitigated oxidative and ionic stress by enhancing nutrient uptake (K?, Ca²?, N?), reducing Na? accumulation, and increasing protein content and membrane stability. The ameliorative effects of mannitol were concentration-dependent, with 100 ppm proving most effective across parameters. In contrast, salinity without mannitol significantly suppressed growth, yield, and quality traits. These findings suggest that mannitol application, particularly at 100 ppm, can enhance wheat salt tolerance, providing a viable, affordable method for enhancing crop production in soils impacted by salt.