A field study was conducted at National Agricultural Research Centre (NARC), Islamabad, during two crop years (2003 - 04) to determine the effect of different weed control methods on the yield and yield components of maize (Zea mays L.). In this study, different weed control methods (chemical, mechanical, hand weeding & their integration) were compared for their efficiency to control various weed species under rain-fed conditions of Pakistan. Among different weed control methods, chemical weeding at 2 - 3 leaf stage of weeds + hand weeding at 50 DAS gave promising results (1.7 g m-2). This was closely followed by mechanical weeding after 20 days of crop sowing with a follow-up hand weeding after 50 days of crop sowing and/or two hand weedings after 20 and 40 days of crop sowing. These weed control methods significantly controlled weeds and enhanced yield (42%) and yield components of wheat during both the study years. The economic analysis of these weed control methods also showed better performance of chemical weeding at 2 - 3 leaf stage of weeds + hand weeding at 50 DAS as compared to rest of the treatments.